GPOEM (Gastric Per-Oral Endoscopic Myotomy)

GPOEM is an advanced endoscopic procedure for patients with refractory gastroparesis who have not found relief with diet changes or medications.

OVERVIEW

What is GPOEM?

GPOEM is an advanced endoscopic procedure performed through the mouth to treat refractory gastroparesis. During the procedure, a thin, flexible camera called an endoscope is used to reach the stomach. The doctor creates a small internal opening in the stomach lining to reach the pylorus, which is the muscular outlet between the stomach and small intestine. A small muscle cut, known as a myotomy, is then made to help the pylorus relax. This allows stomach contents to pass more freely into the small intestine. The internal opening is closed with clips or sutures at the end of the procedure.

HOW TO CHOOSE

Why choose NorCal Integrity Surgery for GPOEM evaluation?

Dr. Colin Dunn focuses on foregut and stomach conditions, performing advanced endoscopic and minimally invasive procedures. This specialized experience is particularly valuable when gastroparesis overlaps with reflux or prior stomach surgery. The goal at NorCal Integrity Surgery is to provide a clear diagnostic plan and a balanced discussion of all treatment options based on your unique clinical history and goals.

THE PROCEDURE

What happens during GPOEM?

The exact plan for GPOEM varies by patient and clinical setting, but the procedure typically involves several key steps performed under general anesthesia.

[01]
Anesthesia

You are usually asleep under general anesthesia to ensure comfort and safety during the endoscopic procedure.

[02]
Endoscope placement

A thin, flexible camera is passed through the mouth and down into the stomach to provide internal access without external incisions.

[03]
Internal access

A small opening is made in the stomach lining to reach the muscle layers of the pylorus.

[04]
Pyloric myotomy

The muscle near the pylorus is carefully cut to reduce resistance at the stomach outlet, helping food pass more easily.

[05]
Closure and monitoring

The internal opening is closed with clips or sutures, and you are observed while waking from anesthesia during early recovery.

PRE-OPERATIVE WORKUP

Preparing for GPOEM

You will receive specific pre-procedure instructions from your care team to ensure the safest and most effective outcome.

Required before surgery

• Confirmed delayed gastric emptying on a properly performed 4-hour test.

• Upper endoscopy report to ensure no mechanical obstruction.

• Fasting for a specific period before the procedure.

• Arranging a responsible adult to provide a ride home.

• Medicine adjustments as directed by your care team.

Sometimes also ordered

• CT scan of the abdomen and pelvis or other relevant imaging.

• Review of medication lists and diabetes glucose records.

• Nutrition planning or medical optimization before the procedure.

WHO IS A CANDIDATE

Who may be considered for GPOEM?

GPOEM is typically reserved for selected adults with refractory gastroparesis whose symptoms remain significant despite appropriate medical care.

Likely good candidates

• Adults with moderate to severe persistent symptoms like nausea or vomiting.

• Patients with confirmed delayed gastric emptying on a 4-hour test.

• Those who have tried dietary changes, medications, and other medical measures without success.

• Patients whose clinical picture suggests the pylorus is contributing to the problem.

May need further evaluation

• Patients with a mechanical obstruction identified on endoscopy or imaging.

• Individuals whose symptoms are primarily due to nerve problems or other stomach disorders.

• Those who have not yet attempted conservative management like diet and medication.

Not sure if you qualify?

Dr. Dunn reviews every case personally. Book a consultation and he'll give you an honest answer — even if that answer is "let's get more testing first."

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RISKS

Risks to be aware of

All medical procedures carry risks, and recovery experiences vary between patients. While GPOEM is less invasive than traditional surgery, it still requires specialized skills and careful post-procedure monitoring.

Common short-term side effects (expected and temporary)

Expected in recovery

• Temporary abdominal pain or discomfort.

• Throat soreness from the endoscope.

Serious risks (uncommon)

• Infection or ulcers near the pylorus.

• Tears in the stomach lining with associated bleeding.

• Rare occurrence of air in the abdomen or chest.

• Formation of scar tissue that may affect long-term benefit.

RECOVERY

What recovery looks like

Follow-up care includes reviewing your response to the procedure and adjusting medications or nutrition plans as needed.

[D1]
Day of surgery

On the day of the procedure, you will be prepared for anesthesia and the endoscopic treatment. Some patients may go home the same day, while others are stayed for observation.

[D4]
First 4 days

Early recovery focuses on managing any throat soreness or abdominal pain. You will likely follow a gradually advancing diet as directed by your care team.

[W1]
Through about 1.5 weeks

Your care team will explain how to monitor symptoms and follow nutrition guidance as you recover.

[W2]
Around 2 weeks

Follow-up focuses on symptoms, nutrition, and any medicine adjustments recommended by your care team.

[M2]
Month 2 onwards

Longer-term recovery focuses on symptoms, nutrition, and follow-up to review your response to treatment.

OUTCOMES

What to expect long-term

Long-term outcomes after GPOEM depend on your specific symptom pattern and the underlying cause of gastroparesis. While many patients experience meaningful relief from nausea and vomiting, the procedure specifically treats resistance at the pylorus and may not address other causes of symptoms like nerve issues or reflux. Ongoing follow-up tests and nutrition support are often part of the long-term management plan.

FAQ

Questions about GPOEM

Who should consider an evaluation for the G-POEM procedure?

G-POEM is typically considered for adults who have refractory gastroparesis, which means their symptoms have not improved enough with standard medical care. You might be a candidate if a properly performed four-hour test has confirmed that your stomach empties too slowly. It is also important that imaging or an upper endoscopy has ruled out any physical blockages. Usually, patients have already tried changing their diet, managing their medications, and optimizing their nutrition before discussing this procedure. Dr. Dunn will review your full medical history, including your symptoms and prior treatment attempts, to see if the pylorus muscle is likely contributing to your health concerns and if this approach is appropriate for your specific situation.

How should I prepare for a G-POEM consultation and procedure?

Preparing for your evaluation starts with gathering your medical records. You should bring your gastric emptying study report, upper endoscopy results, and any relevant imaging like a CT scan. It is also helpful to provide a complete list of your current medications and diabetes records if they apply to you. If you move forward with the procedure, your care team will give you specific instructions. These typically include fasting for a certain period and adjusting your usual medications. Because the procedure requires general anesthesia, you must also arrange for a ride home afterward. Following these steps closely helps ensure your medical team has the information they need for a safe and thorough review of your condition.

What happens during the G-POEM procedure?

The G-POEM procedure is an advanced way to treat gastroparesis without making any external cuts on your body. While you are asleep under general anesthesia, the doctor passes a thin, flexible camera called an endoscope through your mouth and into your stomach. The physician makes a small opening in the stomach lining to reach the pylorus, which is the muscle that acts as the stomach's outlet. A precise cut is made in this muscle to help it relax, allowing food to pass more easily into the small intestine. Finally, the internal opening is closed using small clips or sutures. This internal approach is less invasive than traditional surgery, though it still requires specialized medical skills and careful monitoring.

What should I expect during recovery, and what are the potential risks?

Recovery after G-POEM varies for every patient. Some people stay in the hospital for observation, while others may go home the same day. You may experience temporary throat soreness or abdominal discomfort as you wake from anesthesia. Your care team will help you gradually advance your diet as you heal. While many patients see an improvement in symptoms like nausea and vomiting, results depend on the underlying cause of your condition. It is important to understand the potential risks, which can include infection, ulcers, or bleeding. In rare cases, air may enter the abdomen during the process. Dr. Dunn will discuss these possibilities with you to ensure you have a balanced understanding of what to expect during your recovery.

Ready to stop managing and start fixing?

Most practices hand you discharge papers and wish you luck. We keep working with you, at no extra cost, until all three happen: off your reflux meds, sleeping flat without pillows, and eating your favorite foods again — typically within 30 days of surgery. That's our GERD surgery guarantee.

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